急性缺血性卒中患者缺血再灌注损伤的分子机制与干预策略研究

Acute ischemic stroke(AIS) is one of the leading causes of death and disability worldwide, with persistently high incidence and mortality rates, imposing a heavy economic burden on society and families. Currently, early reperfusion therapy has become a crucial approach to improving patient prognosis. However, this process is complicated by the occurrence of ischemia-reperfusion injury(IRI), which exacerbates brain damage. Understanding the molecular mechanisms of IRI and developing effective intervention strategies are of paramount importance for enhancing the therapeutic efficacy and improving the long-term prognosis of AIS patients. This article comprehensively reviews the progress in the research on the molecular mechanisms of IRI in patients with acute ischemic stroke and discusses current and potential future intervention strategies, aiming to provide a theoretical basis and new perspectives for the development of more effective and safer treatments for IRI.