基层12～30月龄儿童百白破疫苗第3剂迟种影响因素分析

Objective To describe the timeliness of the third dose of diphtheria–tetanus–acellular pertussis vaccine(DTaP-3) among children aged 12～30 months in Huimin Community, Jiashan, and to identify associated factors. Methods Based on Zhejiang Province's Childhood Immunisation Information System, data were retrospectively collected for 166 resident children. Using delayed vaccination of the DTaP-3 vaccine as the outcome, univariate and multivariate Logistic regression analyses were conducted to identify associated risk factors for delayed DTaP-3 vaccination. Odds ratios(OR) and their 95% confidence intervals(95% CI) were calculated. Results A total of 166 children were included, of whom 56 experienced delayed DTaP-3, yielding a delay rate of 33.73%. Compared with the on-time group, the delayed group had significantly higher proportions of floating population status, delayed registration, preterm birth, grandparental care, and prior delay of DTaP dose 1 or 2(P<0.05). Multivariate Logistic regression analysis revealed that delayed vaccination of the second dose of DTaP(aOR=19.527, 95%CI: 5.991～63.653), preterm birth(aOR=7.521, 95%CI: 1.848～30.602), delayed registration(aOR=3.955, 95%CI: 1.224～12.781), and floating household registration(aOR=3.753, 95%CI: 1.271～11.076) were independent risk factors for delayed DTaP-3 vaccination(P<0.05). Conclusion Delayed vaccination of the DTaP-3 vaccine within the jurisdiction is influenced by a combination of prior vaccination history, individual developmental factors, and management considerations. Primary healthcare institutions should utilise information systems to identify high-risk children and implement targeted interventions to improve timely vaccination coverage.