精神分裂症患者激越症状与炎症标志物的相关性研究

Objective To investigate the correlation between serum interleukin-6(IL-6), neutrophil-to-lymphocyte ratio(NLR), and psychiatric symptoms in schizophrenia patients. Methods 45 newly admitted schizophrenia patients with agitation symptoms who were hospitalized at Zhangshan Third People's Hospital from July 2022 to July 2023 were selected as the research group. At the same time, 45 schizophrenia patients without agitation symptoms with matching basic information were selected as the control group. Both groups were assessed using the Positive and Negative Syndrome Scale(PANSS) and PANSS-Excited Component(PANSS-EC). Venous blood samples were collected to measure serum IL-6 levels and calculate NLR values. Results The levels of IL-6 and NLR in the research group were both elevated(IL-6: 3.595±3.056 pg/L vs. 1.500±0.503 pg/L, NLR: 7.399±1.103 vs. 1.327±0.198), and the differences were statistically significant(P<0.05). Analying the research group, the expression of patients' IL-6 PANSS-EC factor score(r=0.52, P<0.05). The NLR value was positively correlated with PANSS-EC(r=0.37, P<0.05). Conclusion Schizophrenia patients with agitation exhibit significantly higher serum IL-6 levels and NLR values compared to non-agitated patients, suggesting these biomarkers may be associated with agitation symptoms in schizophrenia.