左卡尼汀联合重组促红细胞生成素在血液透析中的应用

Abstract: Objective To explore the application effect of l-carnitine combined with recombinant erythropoietin in patients undergoing maintenance hemodialysis. Methods A total of 60 patients who received maintenance hemodialysis in our hospital from January 2024 to December 2024 were selected as research objects. They were randomly divided into the research group (30 cases) and the control group (30 cases) using a randomized controlled grouping method. The control group was treated with recombinant erythropoietin, while the research group was treated with l-carnitine combined with recombinant erythropoietin. The therapeutic effect and the incidence of adverse reactions in both groups were statistically analyzed. The anemia-related biochemical indicators, cardiac function indicators, renal function indicators, oxidative stress indicators, and safety indicators of the two groups were compared before and after treatment. Results Compared with the control group, the total effective rate of patients in the research group was higher. After treatment, hemoglobin (Hb), hematocrit (HCT), ferritin (SF), transferrin saturation (TSAT), reticulocyte count (Ret), serum iron (SI), serum superoxide dismutase (SOD), serum glutathione peroxidase (GSH-Px) levels were higher, blood urea nitrogen (BUN), serum creatinine (Scr), β2-microglobulin (β2-MG), serum malondialdehyde (MDA), heart rate (HR), diastolic blood pressure (DBP), systolic blood pressure (SBP), and D-D (D-dimer) levels were lower, with significant differences between the groups (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Treatment of l-carnitine combined with erythropoietin in maintenance hemodialysis patients can achieve significant curative effects, and can effectively improve their anemia related biochemical indicators, renal function indicators, oxidative stress indicators and safety indicators, with fewer adverse reactions.