年轻浸润性乳腺癌的临床病理特点和治疗预后分析

Abstract: Objective To investigate and analyze the surgical approaches,clinicopathological parameters and prognosis of young patients with invasive breast cancer. Methods The data of 169 patients with invasive breast cancer aged ≤ 40 years in our hospital from January 2015 to may 2020 were retrospectively collected and divided into ≤ 30 years old group (n=58) and 31～40 years old group (n=111) according to age. Results The proportion of stage III was higher in the ≤ 30-year-old group, and the proportion of T4 and N2 and the high expression rate of proliferating cell nuclear antigen (Ki-67) were higher than those in the 31～40-year-old group (P＜0.05). The proportion of breast conserving surgery was higher and the proportion of modified radical surgery was lower in this group (P＜0.05). In molecular typing, the proportion of Luminal type A in ≤ 30 years old group was higher, while that in Luminal type B human epidermal growth factor receptor 2 negative group was lower (P＜0.05). The 5-year follow-up showed that the recurrence and metastasis rate of ≤ 30 years old group was higher (P＜0.05). Conclusion Young patients with invasive breast cancer have faster tumor progression, easier metastasis, high expression of Ki-67 and poor prognosis, which should be diagnosed and treated as soon as possible.