吸入性糖皮质激素对哮喘儿童氧化应激水平的影响

Abstract: Objective This study aims to investigate the impact of inhaled glucocorticoids on oxidative stress levels in children with asthma. Methods A total of 100 children with asthma who were admitted to Peking University First Hospital Ningxia Women’s and Children’s Hospital from March 2023 to March 2025 were selected as the subjects. Using the random number table method, these 100 children were randomly divided into the observation group and the control group, with 50 cases in each group. Patients in the control group were treated with formoterol, while patients in the observation group were treated with formoterol combined with budesonide. The treatment efficiency, oxidative stress-related indicators, inflammatory response-related indicators and adverse reactions of the two groups were compared and analyzed. Results Compared with the control group, the treatment efficacy rate, oxidative stress-related indicators, inflammatory response-related indicators, and the occurrence of adverse reactions in the observation group were all better after treatment, and the differences were statistically significant (P＜0.05). Conclusion The combination of the two drugs can effectively reduce the oxidative damage and inhibit the inflammatory response in patients with asthma. The treatment effect is significant, and it will not increase the probability of adverse reactions. It has high clinical application value.