乙型肝炎疫苗预防接种效果的评估分析

Objective To explore the clinical effect of hepatitis B vaccination. Methods A total of 103 infants and young children who received full-course hepatitis B vaccination from March 2021 to March 2022 were enrolled as the observation subjects. The indicators such as the titer of hepatitis B antibody in children, the response of hepatitis B virus antibody, the conversion of surface antibody to positive, and the levels of different antibodies were recorded. Results One year, two years and three years after vaccination, the titer of hepatitis B antibody in children decreased, and the numerical value in three years after vaccination was lower than that in one year and two years after vaccination (P＜0.05). One year after inoculation, the positive rate of hepatitis B virus surface antibody was higher than that of two and three years after inoculation (P＜0.05). After the first inoculation of hepatitis B vaccine, the highest positive rate of surface antibody was found 24 weeks after inoculation (P＜0.05). Conclusion The implementation of hepatitis B vaccination is of significant importance in reducing the risk of hepatitis B infection in infants and young children. With the extension of vaccination time, the conversion rate of surface antibodies to positive shows an increasing trend. Through supplementary vaccination, the preventive vaccination effect can be further improved.