肿瘤标志物联合临床参数鉴别肺腺体前驱病变及肺腺癌浸润性

Objective To evaluate carcinoembryonic antigen(CEA), squamous cell carcinoma antigen(SCCA), neuron-specific enolase(NSE), carbohydrate antigen 125(CA125), cytokeratin 19 fragment(CYFRA21-1), human epididymis protein 4(HE4), age, and maximum tumor diameter for differentiating stage I lung adenocarcinoma from pulmonary glandular precursor lesions(PGL) and assessing invasion. Methods Eight indicators were compared between 87 adenocarcinoma and 30 PGL cases. Receiver operating characteristic(ROC) curves assessed diagnostic performance. PGL, minimally invasive adenocarcinoma(MIA), and invasive adenocarcinoma(IAC) were compared. Results Age, maximum diameter, CEA, HE4, and CYFRA21-1 were higher in adenocarcinoma than those in the PGL group(P<0.05). Combined area under the curve(AUC) was 0.852. Age, maximum diameter, CEA, and HE4 increased with invasion. CYFRA21-1 was higher only in IAC than PGL. Conclusion Combined detection may assist differential diagnosis between PGL and stage I lung adenocarcinoma and invasion assessment.