慢性乙型肝炎患者乙型肝炎表面抗原定量检测与乙型肝炎病毒脱氧核糖核酸载量的相关性分析

Objective To analyze the correlation between serum hepatitis B surface antigen(HBsAg) quantitative levels and hepatitis B virus deoxyribonucleic acid(HBV-DNA) load in patients with chronic hepatitis B(CHB), and to evaluate the clinical value of quantitative HBsAg in assessing viral replication activity. Methods A total of 120 CHB patients admitted to our hospital from September 2025 to March 2026 were selected as study subjects. Serum HBsAg, hepatitis B e antigen(HBeAg), and HBV-DNA levels were measured. Patients were divided into HBeAgpositive and HBeAg-negative groups based on their HBeAg status. The correlation between HBsAg levels and HBV-DNA load was analyzed. Results Overall, a positive correlation was observed between quantitative HBsAg and HBV-DNA load in the 120 patients(r=0.68, P<0.05). The correlation coefficient in the HBeAgpositive group(r=0.79, P<0.05) was higher than that in the HBeAg-negative group(r=0.35, P<0.05). Conclusion Quantitative HBsAg levels are positively correlated with HBV-DNA load in CHB patients, with a stronger correlation observed in HBeAg-positive individuals. Quantitative HBsAg can serve as an auxiliary indicator for evaluating viral replication activity.