藏药九味牛黄丸治疗慢性乙型病毒性肝炎的临床研究

Objective To investigate the efficacy of Tibetan medicine Jiuwei Niuhuang Wan in the treatment of chronic hepatitis B virus infection. Methods 124 patients in our hospital were randomly divided into an observation group and a control group using a random number table. Each group consisted of 62 patients. The observation group was treated with Jiuwei Niuhuang Wan, while the control group was treated with entecavir, for a course of 24 weeks. The clinical efficacy and adverse reactions of both groups were monitored. Hepatitis B e antigen(HBeAg) levels and hepatitis B virus deoxyribonucleic acid(HBV DNA) negativity rates were compared before and after treatment. Liver function indicators—alanine aminotransferase(ALT), aspartate aminotransferase(AST), total bilirubin(TBIL), and total bile acids(TBA)—as well as the levels of interleukin-17(IL-17), interleukin-37(IL-37), serum C-X-C motif chemokine ligand 13(CXCL-13), macrophage inflammatory protein-1β(MIP-1β), and macrophage migration inhibitory factor(MIF) were compared. Results After treatment, the total effective rate in the control group was 83.87%, significantly lower than the 93.54% in the observation group(P<0.05). After treatment, the liver function indicators AST, ALT, TBIL, and TBA in both groups decreased significantly(P<0.05), with a more pronounced reduction in the observation group(P<0.05). After treatment, the HBV DNA and HBeAg negativity rates in the observation group were higher than those in the control group. Additionally, serum levels of CXCL-13, IL-37, IL-17, MIP-1β, and MIF in both groups were significantly improved(P<0.05), with the most significant improvement observed in the observation group(P<0.05). No serious adverse reactions occurred in either group during the treatment period. The difference was not statistically significant(P>0.05). Conclusion Tibetan medicine Jiuwei Niuhuang Wan in the treatment of chronic hepatitis B can promote the recovery of liver function and facilitate HBV DNA seroconversion, demonstrating significant and reliable efficacy with good clinical promotion value.