基于 2 668 样本分析苯系物暴露情况与外周血细胞计数的相关性

Abstract: Objective This study aims to analyze the correlation between exposure to benzene series substances and peripheral blood cell counts. Methods This study selected the occupational health examination data of the occupational population exposed to benzene series substances in Haian City from January 2022 to December 2022 for research. They were divided into two groups according to the number of types of substances exposed to, namely benzene, toluene, xylene and styrene. Those exposed to more than two types were classified as the study group (n=1334), and those exposed to two types or less were classified as the control group (n=1 334). The t-test or chi-square test was used to compare the effects of benzene series exposure on the counts of each cell between groups. Receiver operating characteristic curve (ROC) analysis was performed on the data using GraphPad Prism 8. The Spearman correlation analysis method was used to analyze the correlation between the exposure to benzene series substances and the count levels of each cell. Results The monocyte count, white blood cell count and neutrophil count in the study group were significantly lower than those in the control group, while the lymphocyte count was significantly higher. The differences were statistically significant (P＜0.001). The number of monocytes (r=-0.69), the number of white blood cells (r=-0.95), and the number of neutrophils (r=-0.86) were negatively correlated with the exposure level of benzene series, while the number of lymphocytes (r=0.63) was positively correlated with the exposure level of benzene series. The area under the ROC curve of monocyte count (AUC) was 0.647. The AUC of white blood cell count was 0.871. The AUC of neutrophil count was 0.917. The AUC of lymphocyte count was 0.785. Conclusion Exposure to benzene series substances can reduce the levels of monocyte count, white blood cell count and neutrophil count, while inducing an increase in lymphocyte count.