冠状动脉狭窄严重程度的相关因素研究

Abstract: Objective To investigate whether lipoprotein-associated phospholipase A2(Lp-PLA2) is associated with the severity of coronary artery stenosis in coronary atherosclerotic heart disease (coronary heart disease). Methods 252 hospitalized patients undergoing coronary angiography(CAG) were selected for retrospective study. These patients were divided into coronary heart disease group (191 cases) and control group (61 cases) based on the results of CAG. The difference of clinical data between the two groups was compared. The relationship between various factors and the Gensini score (for assessing coronary artery stenosis) was studied by multiple linear regression analysis. The correlation between Lp-PLA2 and other clinical parameters was studied through Pearson correlation analysis. Results The levels of age, Lp-PLA2, white blood cells (WBC) and D-dimer in coronary heart disease group were higher than the control group (P＜0.05). The thyroid stimulating hormone (TSH) in coronary heart disease group was lower than that in the control group (P＜0.05). Lp-PLA2 (β= 0.164, 95%CI: 0.001～0.068) and low-density lipoprotein (LDL) (β= 0.276, 95%CI: 2.079～7.564) were independent predictors of the severity of coronary artery stenosis. Pearson correlation analysis showed that Lp-PLA2 was positively correlated with WBC (r= 0.262, P＜0.05), while Lp-PLA2 was negatively correlated with age (r=-0.147, P＜ 0.05) and apolipoprotein A (apoA) (r=-0.201, P＜ 0.05). In addition, Lp-PLA2 in male patients with coronary heart disease was higher than that in female patients(P＜0.05). Conclusion Lp-PLA2 was higher in patients with coronary heart disease than that in patients of the control group. Lp-PLA2 and LDL were independent predictors of coronary artery severity in patients with coronary heart disease.