2型糖尿病患者合并骨质疏松症的骨代谢水平及独立危险因素研究

Objective To investigate the characteristics of bone metabolism and independent risk factors in type 2 diabetes patients with osteoporosis. Methods 128 patients with type 2 diabetes aged 30 to 60 years old in Gaomi People' s Hospital in 2024 were selected and were grouped according to the low-density lipoprotein cholesterol(LDL-C) level(68 cases in the normal group: 1.5～3.36 mmol/L. 60 cases in the abnormal group: ≥3.36 mmol/L). Glycated hemoglobin A1c(HbA1c) and bone metabolism markers [procollagen I N-terminal propeptide(PINP), bonegla protein(BGP), 25-hydroxy-vitamin(25-OH VD), parathyroid hormone(PTH), β-cross-linked C-tetopeptide of type I collagen(β-CTX)] were measured in both groups. Results Significant differences in PTH, PINP, BGP, β-CTX, and HbA1c were observed between groups. Among them, the levels of PINP and BGP in the normal LDL-C group were significantly higher than those in the high LDL-C group, while PTH, β-CTX, and HbA1c were relatively lower, and the differences were statistically significant(P<0.05). Further correlation analysis revealed that LDL-C and HbA1c were negatively correlated with PINP, BGP, and 25-OH VD levels, and positively correlated with β-CTX levels. Multiple linear regression analysis showed that LDL-C and HbA1c were independent risk factors affecting bone metabolism in type 2 diabetes patients. Conclusion LDL-C level is one of the key factors affecting bone metabolism in type 2 diabetes patients. In addition, HbA1c level also showed a strong correlation with bone metabolism indicators, further emphasizing the negative impact of diabetes on bone health. LDL-C and HbA1c are independent risk factors affecting bone metabolism in patients with type 2 diabetes. Therefore, clinicians and patients should recognize the importance of LDL-C and HbA1c in bone metabolism in patients with type 2 diabetes, and take effective measures to intervene.